Home » Uncategorized » Two common flavoring chemicals in e-cigarettes can damage lung cells

Two common flavoring chemicals in e-cigarettes can damage lung cells

In lab tests, the additives, including one associated with ‘popcorn lung,’ decrease the numbers of cells that keep airways clean

acs blog

Known for its buttery aroma, diacetyl is a popular flavorant in the food industry. In the early 2000s, studies revealed an association between the compound and bronchiolitis obliterans, or “popcorn lung,” a disease first observed in workers at popcorn factories that causes dry cough and wheezing. In 2012, the US Flavor and Extract Manufacturers Association issued workplace exposure limits for diacetyl and its close analog 2,3-pentanedione and recommended that the chemicals carry a warning label explaining that inhaling fumes containing the compounds could be harmful.


Diacetyl is also the most common of several hundred flavoring chemicals used in e-cigarettes, and a 2016 study of 51 e-cigarette products found that more than half contained 2,3-pentanedione. Now, a multidisciplinary team of researchers at the Harvard T. H. Chan School of Public Health and the University of Pennsylvania has evaluated the effect of the two flavoring chemicals on human bronchial epithelial cells in culture and proposed a possible mechanism for how they could impair lung function (Sci. Rep. 2019, DOI: 10.1038/s41598-018-37913-9).


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Balani Infotech

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