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Monthly Archives: November 2018

How to Harness Your Anxiety

Research shows that we can tame anxiety to use it as a resource.

psycology

The New York Times

By Alicia H. Clark

Anxiety has long been one of the most feared enemies in our emotional canon. We fear its arrival, feel helpless and trapped under its spell, and grant it power to overtake us in new, exciting and challenging situations. But what if we’ve been going about it all wrong?

Research shows that anxiety can actually be a pathway to our best selves. A range of new neuroscience, along with ideas from ancient philosophy, Charles Darwin, early social scientists and positive psychology, have all pointed in this direction.

To be sure, severe anxiety can be debilitating. But for many people who experience it at more moderate levels it can be helpful, if we are open enough to embrace and reframe it.

For example, if anxiety is holding you back from applying for a new job, tell yourself that the feeling of your heart racing, which you thought was the discomfort of anxiety, is actually a crackle of excitement. This can help motivate you to apply for the job rather than shrinking from the opportunity.

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Balani Infotech
www.balaniinfotech.com

Brain-eating amoebae halted by silver nanoparticles

“Clinically-Approved Drugs Against CNS Diseases as Potential Therapeutic Agents to Target Brain-Eating Amoebae”

ACS Chemical Neuroscience

brain

Halloween is just around the corner, and some people will celebrate by watching scary movies about brain-eating zombies. But even more frightening are real-life parasites that feed on the human brain, and they can be harder to kill than their horror-movie counterparts. Now, researchers have developed silver nanoparticles coated with anti-seizure drugs that can kill brain-eating amoebae while sparing human cells. The researchers report their results in ACS Chemical Neuroscience.

Although infections with brain-eating amoebae (Naegleria fowleri) are rare, they are almost always deadly. Most cases result from inhaling warm, dirty water in ponds, hot springs or unchlorinated swimming pools. Another species, Acanthamoeba castellanii, can cause blindness by entering the eyes through dirty contact lenses. Common treatments include antimicrobial drugs, but they often cause severe side effects because of the high doses required for them to enter the brain. Ayaz Anwar and colleagues wondered if three anti-seizure drugs — diazepam, phenobarbitone and phenytoin — could kill amoebae, alone or in combination with silver nanoparticles. The drugs are already approved by the U.S. Food and Drug Administration and are known to cross the blood-brain barrier. The researchers reasoned that they might be more effective when attached to silver nanoparticles, which can improve the delivery of some drugs and also have their own antimicrobial effects.

The team chemically attached the drugs to silver nanoparticles and examined their ability to kill amoebae. They found that each of the three drugs alone could kill N. fowleri and A. castellanii, but they worked much better when bound to silver nanoparticles. The drug-nanoparticle combos protected human cells from the microbes, increasing their survival rate compared with untreated infected human cells. The researchers propose that these repurposed drugs, aided by the nanoparticles, might kill amoebae by binding to protein receptors or ion channels on the single-celled organism’s membrane.

Note: ACS does not conduct research, but publishes and publicizes peer-reviewed scientific studies.

 

Published By -
Balani Infotech
www.balaniinfotech.com