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Monthly Archives: April 2018

3 Mental Exercises That Will Bring You Joy

AORN_Blog_3 Mental Exercises That Will Bring You Joy_18-4-18

Nurses rarely consider their own feelings or how their feelings impact patients, families, and even co-workers, but understanding what you are feeling is critical for our health.

And, it turns out that our feelings are far more transparent than we think, according to Amanda Gore, CEO of The Joy Project and a communications expert who uses neuroscience, epigenetics, emotional intelligence, and positive psychology to help others feel great about themselves, dissolve fear, and build resilience.

It’s these non-verbal exchanges that can establish or foster either positive or negative relationships in your workplace. At a deeper level, how you feel about yourself colors everything in your life, including your interactions with co-workers, Gore cautions.

The good news is that we can rewire our brains by consciously choosing to think in a more positive way. To train your thoughts and feelings toward positivity, she suggests these three mental exercises.

1. Observe Your Thinking

Be conscious of your internal narrative about yourself and others. Instead of thinking about what you don’t like, choose one thing you believe is positive about yourself, such as your strength in an aspect of clinical care, and fix your brain on that positive thing throughout the day.

2. Be Present

Work to leave worries of the past and future behind you. Instead, practice focusing on the now. This will reinforce your ability to observe and reinforce your thinking for positivity and gradually weaken old patterns of negative thinking.

3. Be “Wise-Selfish”

The Dalai Lama tells us to be “wise selfish” by recognizing that “our own long-term individual interest lies in the welfare of everyone.” Perioperative nurses are in nursing because they want to help others, but they may forget about themselves in the process. Taking care of yourself gives you more energy to care for others. Know more

Published By- 
Balani Infotech Pvt. Ltd.

Listening for the Cosmic Hum of Black Holes

A new analysis technique would allow the gravitational-wave “background” from distant black hole mergers to be detected in days instead of years.

APS Blog_Listening for the Cosmic Hum of Black Holes_17-4-18

The recent detection of gravitational waves from outer space has ushered in a new era of astronomy. To date, the teams behind these detections—the Laser Interferometer Gravitational-Wave Observatory (LIGO) and Virgo collaborations—have observed waves from a handful of black hole mergers [15] and one binary neutron star merger [6]. But these detected events are just the tip of the iceberg. Estimates suggest that a pair of stellar-mass black holes, like the ones LIGO and Virgo observed, merge somewhere in the Universe every few minutes. For neutron star binaries, mergers occur every 15 seconds or so. Yet only a few of these mergers are sufficiently close by to produce “gold-plated” detections. A new paper explains how best to combine the signals from the multitude of less prominent merger events to reveal information about the Universe’s entire black hole binary population [7]. The proposed technique, from Rory Smith and Eric Thrane of Monash University in Australia, will allow us to detect the background “rumble” of distant mergers far sooner than we would be using traditional methods.

LIGO and Virgo detect gravitational waves by looking for minute changes in the distance between mirrors on either end of kilometer-scale laser interferometers. A passing gravitational wave effectively wiggles the mirrors back and forth, producing an oscillating signal that lasts a fraction of a second for black hole mergers and up to a few minutes for neutron star mergers. The US-based LIGO is comprised of two such interferometers separated by 3000 km, while Virgo has one interferometer in Italy.

The LIGO and Virgo teams consider a signal “significant” if, upon analysis, it has a greater than 99.99% probability of being of astrophysical origin. The five black hole mergers and the neutron star merger reported to date all fall into this category. By comparing the gravitational-wave signals from these events to predictions based on Einstein’s theory of gravity, the researchers inferred the masses, spins, and sky location of the sources. The detections have also been used to infer the merger rate of black holes and neutron stars throughout the Universe. Read More

Published By- 
Balani Infotech Pvt. Ltd.

MLL leukemia induction by t(9;11) Chromosomal Translocation in Human Hematopoietic Stem Cells using Genome Editing

ASH Blood Blog_16-4-18

Key Points

  • Genome editing induces t(9;11) chromosomal translocations and transforms primary CD34+ human cord blood cells leading to acute leukemia.

  • CD9 is upregulated in primary t(9;11) cells and is a useful marker for the enrichment of genome-edited MLL-rearranged cells in vitro.

Genome editing provides a potential approach to model de novo leukemogenesis in the primary human hematopoietic stem and progenitor cells (HSPCs) through induction of chromosomal translocations by targeted DNA double-strand breaks. However, the very low efficiency of translocations and lack of markers for translocated cells serve as barriers to their characterization and model development. Here, we used transcription activator-like effector nucleases to generate t(9;11) chromosomal translocations encoding MLL-AF9 and reciprocal AF9-MLL fusion products in CD34+human cord blood cells. Selected cytokine combinations enabled monoclonal outgrowth and immortalization of initially rare translocated cells, which were distinguished by elevated MLL target gene expression, high surface CD9 expression, and increased colony-forming ability. Subsequent transplantation into immune-compromised mice induced myeloid leukemias within 48 weeks, whose pathologic and molecular features extensively overlap with de novo patient MLL-rearranged leukemias. No secondary pathogenic mutations were revealed by targeted exome sequencing and whole genome RNA-sequencing analyses, suggesting the genetic sufficiency of t(9;11) translocation for leukemia development from human HSPCs. Thus, genome editing enables modeling of human acute MLL-rearranged leukemia in vivo, reflecting the genetic simplicity of this disease, and provides an experimental platform for biological and disease-modeling applications. Read more

Published By- 
Balani Infotech Pvt. Ltd.

To Help Lower Blood Pressure, Have Patients Measure It Themselves


A trial supports self-monitoring over clinic readings for titrating antihypertensive therapy.

Many physicians review patient-collected blood pressure (BP) readings when titrating antihypertensive medications, but evidence supporting this approach has been mixed. British researchers randomized 1182 patients with uncontrolled hypertension (office BP, ≥140/90 mm Hg, despite as many as 3 antihypertensives) to usual care (clinic BP readings), self-monitoring (twice-daily BP readings for 1 week each month mailed in; instructions to contact the physician for very high or very low readings), or telemonitoring (twice-daily BP readings for 1 week, submitted via monthly text messaging; prompts to contact the physician for very high or very low readings or elevated average BPs).

At baseline, mean office-measured systolic BP was ≈153 mm Hg in all three groups. After 12 months, mean office-measured systolic BP was significantly lower with self-monitoring and tele-monitoring than with usual care (137.0, 136.0, and 140.4 mm Hg, respectively); diastolic BPs remained similar in all three groups. The differences in systolic BP appeared to be driven by a significantly greater number of medications prescribed to the intervention groups than to the usual-care group. Know more

Published By- 
Balani Infotech Pvt. Ltd.


ExamSoft- Tool to Optimize Assessment in Higher Education

Examsoft- Assessment made easier

The rapid evolution of technology over the previous forty years has driven educational programs to question how they can leverage newly innovated technologies to optimize the assessment process. It’s no mystery that educators and assessment administrators are incredibly overworked, but with the right technological tools, they can streamline the entire assessment process, making their lives a lot easier and more efficient in the long run.

A Simple Way to Manage Assessment

When trying to manage the substantial workload that teachers are responsible for, optimization and efficiency are key. ExamSoft’s embedded-assessment platform was created specifically to minimise this workload for educators by streamlining the entire assessment process into a single platform. Having the ability to use a single intuitive platform for question banking, exam creation, hosting, grading, and reporting means less time managing assessments and more time for teaching.

Assessment Blueprinting Made Easy

Preparing students for licensure or board exams is no small feat for educational programs, but with solid assessment blueprints, students can be more adequately prepared. ExamSoft’s embedded-assessment platform provides educators and administrators with the technology to map out an exact assessment blueprint for specific licensure or board exam topics and competencies—helping to ensure students will be ready on licensure or board exam day.

Efficiency and optimization are the end goals for educators because when teachers are spending the majority of their time managing and developing the assessment process, students receive less support. ExamSoft’s embedded-assessment platform gives educators the all-encompassing tool that does the heavy lifting—allowing them to focus on what we know is most important: the students.

Don’t waste any more of your valuable time: schedule a demo with us today.

Published By- 
Balani Infotech Pvt. Ltd.

How to Get an Incredible Professional Headshot

ACS Blog_Professional Headshot_9-4-18

Like it or not, presentation matters. It’s important to your career to look your best in person and in digital and print materials related to your work. That’s why you need a high-resolution professional headshot on hand that you can send out as needed.

A headshot is a posed photograph that focuses on a person’s head and face. They’re the pictures you see when you look at people’s profiles on business, university, and lab websites, as well as next to the biographies of speakers and prize winners online or in print.

It’s important to have a professional-looking, high-resolution professional headshot on hand and ready to send out on short notice to a reporter who wants to write an article about you, a committee that wants to give you an award, or anyone else who wants to recognize your work online or in print.

Don’t make the mistake of thinking you can just use any old photo. Use these tips to make sure your headshot is sending the right signals.

Get a Professional- Consider having a professional photographer take your headshots. Be sure to check out a photographer’s portfolio before booking them. Do they have a deep catalog of work? Do you like their photos? Do they take headshots that match the style you want to convey?

Do it Yourself – If you can’t get a professional, don’t give up. Modern digital cameras and even some smartphones can still take appealing headshots. Take the biggest, highest-resolution photo you can and you’l be able to use it for everything from businesscards to banners.

Getting the Right Look- No matter who takes the photos, make sure you’re standing in the right light. Take your photos at a high angle. You want the camera to be looking down at you ever so slightly. Tilt your head a little to one side.

No Matter What- Dress as if you’re about to interview for your dream job. Wear clothing that fits you well and doesn’t clash with your background. Stand up straight, with your shoulders back and your chest out. Good posture will improve your body language and make you look more professional. Smile, but don’t overdo it. Strive to appear confident and welcoming. Know more

Published By- 
Balani Infotech Pvt. Ltd.

What happens when lab animals go wild

PNAS_Blog_6-4-18Experiments on mice living in more natural habitats can deliver results dramatically different from those in traditional laboratories—with profound implications for biomedical science.

In the summer of 2015, a pioneering band of laboratory mice did something their ancestors hadn’t done for roughly 1,000 generations—they went outside.

It was hardly a trek into the wilderness. The 90 mice were fenced into pens, with feeding stations providing all the mouse chow they could eat and aluminum pie plates dangling over their heads to deter passing hawks. Still, it was a world away from their former home in the laboratory of Andrea Graham, an ecological and evolutionary immunologist at Princeton University. These mice could now roam around an area of roughly 180 square meters, feeling the dirt under their feet and rain on their backs.

Some studies, for example, have already shown that experiments on mice in a barn-like setting can uncover a drug’s potential side effects, which traditional preclinical research had missed. And Graham’s results from the nematode study, which used a nematode-resistant strain of mouse, were “just eye-popping,” she says. A few weeks after she infected both indoor and outdoor mice with nematodes, the outdoor group harbored massive infections, with a mass of worms 100 times greater than the indoor group

Translation Trouble

Results, Reinterpreted

A Spectrum of Wildness

Making Better Models

Researchers have good reason to establish a controlled environment, long a hallmark of scientific rigor. And as some start to bring their lab animals into wild territory, they grapple with many questions: What is the best way to mimic the wild? How should researchers monitor animals without disturbing their environment? And how much control can they really afford to give up before experiments become irreproducible or logistically and financially intractable? Read More


Bedrock Holds Unexpected Source of Global Nitrogen


While nitrogen within terrestrial soils and vegetation is largely thought to come from the atmosphere, a new study in the April 6 issue of Science points to a previously underestimated source: weathered bedrock.

Since the availability of nitrogen within ecosystems is essential for plant growth, which in turn modulates the amount of planet-warming atmospheric carbon that can be stored in these ecosystems, the study authors note that their findings could have important implications for global climate change.

The research team led by Benjamin Houlton of University of California, Davis suggests that weathering of rock contributes 6% to 17% of the total terrestrial nitrogen budget, or 11 to 18 teragrams of nitrogen annually, an amount that rivals the level of nitrogen contributed from the atmosphere.

“The biggest surprise to us was how large the flux of rock nitrogen was globally and especially that rocks bested atmospheric sources of nitrogen in many high latitude and mountainous ecosystems,” said Houlton. “Our past work had indicated this possibility, but to see that all three basic approaches were given consistently large numbers, despite different data sets and assumptions, was surprising.” Know more

Published By- 
Balani Infotech Pvt. Ltd.

A clock that will still tick in 10 millennia

A prototype of the 10,000 year clock


Time keeping machines aren’t always built to last, but some do manage to stand the test of time. The Cronulla Clock Tower houses a clock that’s almost 250 years old, for example; the clock in England’s Salisbury Cathedral is still ticking 630 years after it was built.

But there’s a group of people aiming to put these clocks to shame. Buried deep into a mountain in the United States desert, there’s a clock that should keep ticking for 10,000 years.

It takes a lot of engineering to keep time for ten millennia. For one thing, you will need a source of power that will always be available. This clock uses a power source we can be sure will always be around – changes in temperature. It’s powered by mechanical energy harvested from sunlight as well as the people that visit it.

Every day, as the environment warms up, special parts of the clock expand. Every night they shrink again as the air cools. This movement is enough to keep the timekeeper ticking.

The 10,000 year clock has been under construction for many years. Recently, the team have started installing the clock into its purpose built home – an underground chamber drilled into the heart of a mountain in Texas.

We will all be long dead before this remarkable clock marks its 10th millennium. Will it still be ticking? We can only hope. Know More

Published By- 
Balani Infotech Pvt. Ltd.

The First Step To Overcoming Procrastination: Know Thyself

Do you have a Procrastinator Personality?

APA Blog_Overcoming Procrastination

Procrastination is one of the most damaging characteristics that students display because it robs them of good grades and prevents them from maintaining productive and healthy relationships with their teachers, families and friends. Procrastination can have both external (e.g., situations involving work overloads) and internal causes (e.g., personality characteristics).

The following six procrastinator personalities identified by Sapadin (2012) in her book “How to Beat Procrastination in the Digital Age: 6 Unique Change Programs for 6 Personality Styles” are examples of the internal causes that can fuel procrastination. If you are a procrastinator, you can use Appleby’s Maxims to begin the process of decreasing your tendency to procrastinate. You can accomplish the first of these maxims (“Know thyself.”) by using the following six descriptions from Sapadin’s book to identify and understand your own procrastination style or combination of styles.  Next, you can use the strategies from Sapadin’s book to accomplish the second maxim (“Be true to thyself.”) by creating a plan to help you overcome—or at least begin to diminish—your inclination to procrastinate.  Finally, it will be your responsibility to actually accomplish the third maxim (“Just do it.”) by putting your plan into action now, not sometime in the future.

Here are Sapadin’s six procrastination styles. Do you recognize yourself in one or more of them?

  1. The perfectionist
  2. The dreamer
  3. The worrier
  4. The crisis-maker
  5. The defier
  6. The pleaser

Do you recognize yourself in one or more of these descriptions? If your answer is yes, then you have taken the first step in a journey that can transform you into a happier and more productive person. But don’t forget that this journey has the following three parts:

  • Know thyself.
  • Be true to thyself, and then…
  • Just do it today, not tomorrow. Read More